First-line and second-line antiretroviral therapy

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First-line and second-line antiretroviral therapy.

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Association of First-Line and Second-Line Antiretroviral Therapy Adherence

BACKGROUND Adherence to first-line antiretroviral therapy (ART) may be an important indicator of adherence to second-line ART. Evaluating this relationship may be critical to identify patients at high risk for second-line failure, thereby exhausting their treatment options, and to intervene and improve patient outcomes. METHODS Adolescents and adults (n = 436) receiving second-line ART were a...

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Second-line failure and first experience with third-line antiretroviral therapy in Mumbai, India

BACKGROUND There are limited data on the failure of second-line antiretroviral therapy (ART) and the use of third-line ART in people living with HIV in resource-limited settings. Since 2011, the Médecins Sans Frontières (MSF) HIV/tuberculosis programme in Mumbai, India, has been providing third-line ART to patients in care. OBJECTIVE To describe the experiences and programmatic challenges dur...

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Implication of First-Line Antiretroviral Therapy Choice on Second-Line Options

Background Although there are a number of studies comparing the currently recommended preferred and alternative first-line (1L) antiretroviral therapy (ART) regimens on clinical outcomes, there are limited data examining the impact of 1L regimen choice and duration of virologic failure (VF) on accumulation of drug resistance mutations (DRM). The patterns of DRM from patients failing zidovudine ...

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assessing the efficacy of second-line antiretroviral treatment for hiv patients failing first-line antiretroviral therapy in iran: a cohort study

there are limited documents about hiv patients switched to second-line antiretroviral therapy (art) in resource-limited countries. we aimed to assess the efficacy of second-line art for hiv patients following first-line art failure. this was a cohort study of hiv/aids patients with first-line art treatment failure switched to second-line art between january 2004 and march 2014, who followed for...

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ژورنال

عنوان ژورنال: The Lancet

سال: 2004

ISSN: 0140-6736

DOI: 10.1016/s0140-6736(04)16716-0